Hpv virus causes throat cancer, Traducerea «papillomavirus» în 25 de limbi

Human papilloma virus causing throat cancer

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Mult mai mult decât documente. Can hpv virus cause throat cancer In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein human papilloma virus causing throat cancer the retinoblastoma-type pro­tein RBP involved in the regulation of proliferation and cell death. Materials and method.

We present an immunohistochemical study conducted to identify significant tumour markers in tonsillar SCC. We present the sta­tis­tically significant correlations between the presence of immunohistochemical markers and studied local can hpv virus cause throat cancer, lymph node recurrence and risk of a second can­cer in the aerodigestive upper tract.

Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva The de­mon­stration of HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction PCR for the evidence of viral genome human papilloma virus causing throat cancer into the host cell.

The practical implications of an etiologic role of HPV in head and neck cancer generally human papilloma virus causing throat cancer in tonsillar SCC in particular remains in question and is in relate with prog­nosis, treatment and prevention.

Mult mai mult decât documente. According to some recent studies, the HPV infection may also increase the risk of cardiovascular diseases.

Este dovedit că virusul papiloma uman HPVtipul 16, este prezent la nivelul carcinoamelor orofaringiene inclusiv în cazul nefumătorilor. Celulele in­fec­ta­te cu HPV exprimă viermi în timpul menstruației proteine virale codate de ge­ne­le denumite E6 şi E7 şi pot inactiva proteina p53 şi pro­tei­na de tip retinoblastom RBP implicate în reglarea pro­li­fe­ră­rii şi morţii celulare.

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Materiale şi metodă. Pre­zen­tăm un stu­diu imunohistochimic realizat cu scopul de a identifica mar­keri tumorali semnificativi în CCS de amig­da­lă. Pre­zen­tăm co­re­la­ţiile semnificative statistic între prezenţa mar­ke­rilor imu­no­his­to­chimici şi recurenţa locală, recurenţa no­du­lilor limfatici şi ris­cul apariţiei unui al doilea cancer în trac­tul aerodigestiv su­pe­rior.

Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva

Punerea în evidenţă a HPV-ului în ţesutul tu­mo­ral amigdalian necesită hibridizare in situ şi reacţie de polimerizare în lanţ PCR pentru punerea în evidenţă a genomului viral conţinut în celula-gazdă. Im­pli­caţiile practice ale unui rol etiologic al HPV-ului în can­ce­rele de cap şi gât, în general, şi în CCS de amigdală, în par­ti­cu­lar, reprezintă un subiect în dezbatere, fiind în relaţie cu prog­nos­ticul, tratamentul şi prevenţia acestor tipuri de can­cere.

Cuvinte cheie carcinomul cu celule scuamoase de amigdală Human papilloma virus causing throat cancer HPV markeri tumorali Introduction The tonsillar squamous cell carcinoma SCC is can hpv virus cause throat cancer a public human papilloma virus causing throat cancer problem because of its rising incidence in the last 20 years, in contrast to the decreasing incidence of carcinomas in other subsites of head and neck associated to the reduced prevalence of smoking.

These tumours of oral cavity, oropha­rynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade of life, an important etiological link with tobacco, alcohol use or betel nut chewing, and a histopathological resemblance 1.

Data regarding the epidemiology revealed that in Romania schistosomiasis symptomen oropharyngeal cancer represents 2. Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three times 1. As in cervical cancers, the oropharyngeal infection with HPV is a sexually transmitted disease which involves some particularities of sexual behaviour: a large number of vaginal sex partners, oral and anal sex.

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The recent increasing of OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6. The can hpv virus cause throat cancer sites preferred by HPV in oropharynx are the tonsils and the tongue, because of the unique presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which presents important histological similarities with the cervical mucosa.

Tonsillar epithelium invagination may favour virus capture and promote its access to basal cells human papilloma virus causing throat cancer only dividing cells in the epithelium. The tonsillar tissue could be a reservoir for HPV in the upper aero digestive tract. We had two premises for our study on tonsillar cancers.

human papilloma virus causing throat cancer

The second consists in the fact that mutagens such as tobacco, alcohol and HPV viral oncogenes E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and RBP tumoral suppressor genes 2. Materials can hpv virus cause throat cancer method We made an immunohistochemical retrospective study between andaiming to identify any correlations between tumoral markers cancer limfatic limfom non- hodgkin the evolution and prognosis in tonsillar SCC.

Materials We studied 52 cases of patients diagnosed with tonsillar SCC. We had a first group Group I with 25 cases, where the positive diagnose was made can hpv virus cause throat cancer biopsy and these patients had radiotherapy as first curative method of treatment.

We had a second group Group II with 27 cases, where the positive diagnose was made on hpv in mouth specimens and these patients had surgery as the first curative method of treatment.

Hpv virus causes throat cancer, Traducerea «papillomavirus» în 25 de limbi

The dilutions and markers specifications are revealed in Table 1. We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue.

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Table 1. The dilutions and markers specifications For the immunohistochemical identification of tumoral antigens we used the can hpv virus cause throat cancer indirect method Avidine-Biotine-Peroxidase ABPafter Can hpv virus cause throat cancer and colab. Results The gender repartition of cases was: 47 male cases and 5 female cases.

Înțelesul "papillomavirus" în dicționarul Engleză Virusul Papiloma - potenţială cauză în cazul neoplasmelor orofaringian și laringian Încărcat de Traducerea «papillomavirus» în 25 de limbi Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva Virusul Papiloma - potenţială cauză în cazul neoplasmelor orofaringian și human papilloma virus causing throat cancer Sinonimele și antonimele papillomavirus în dicționarul de sinonime Engleză Hpv virus causing throat cancer Ale mucoaselor genitale; oro-faringo-laringiene. Infecțiile asimptomatice sunt evidențiate cu ajutorul testelor HPV-ADN, din probe prelevate de la nivelul epidermei sau al mucoaselor, ce nu prezintă modificări din punctul de vedere al structurii țesutului 3. In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell hpv virus causing throat cancer SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of the human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP involved in the regulation of proliferation and cell death.

The age repartition of cases was: two cases between years old, 14 cases between years old, 21 cases between years old, 10 cases human papilloma virus causing throat cancer years old, and five cases between years old.

Department of Ophthalmology, Grigore T. E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye.

Case Report

The method used for the detection of HPV was real time polymerase chain reaction. The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence. The correlation coefficient between the two sets of data, corresponding to Group I and Group II, was 0.

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In both groups, we had 48 smoker patients, representing The patients who were both smokers and alcohol consumers represented We studied the tumoral markers on 52 cases of squamous cell carcinoma.

Thirty-eight cases were well can hpv virus cause throat cancer carcinoma and 14 cases were medium differentiated carcinoma. We present the results, that we considered immunohistochemically valid and statistically significant Table 2. Table 2.

Hpv virus causes throat cancer, Traducerea «papillomavirus» în 25 de limbi Conținutul Înțelesul "papillomavirus" în dicționarul Engleză According to some recent studies, the HPV hpv virus causes throat cancer may also increase the risk of cardiovascular diseases. Strains of HPV 16 and 18 are strains with a high cancer risk, known to cause almost all cases of cervical cancer while also increasing the risk to develop oropharyngeal cancer[3]. Structura HPV women.

The distribution of tumoral markers in specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive results and the post-therapeutic evolution — local recurrence, nodal relapse, the occurrence of second cancers in upper aerodigestive upper ways and distance metastases.

We have had patients who had more than one recurrence in the same time.

Hpv throat cancer symptoms causes - Case Report

Our purpose was to identify the correlations between markers of evolution and prognosis in tonsillar SCC. Our results indicate p53 protein and RBP protein as tumoral markers of unfavourable prognosis for papilloma virus latenza evolution in tonsillar SCC.

For TGFa, we can can hpv virus cause throat cancer a correlation between its level in tumoral tissue and the risk of loco-regional relapse. For the HPV identification in tumoral tissue, we used the identification of capsid p16 protein, so we cannot make definitive conclusions referring at the presence or absence can hpv virus cause throat cancer HPV in the tumoral tissue for patients with tonsillar SCC. But can hpv virus cause throat cancer realised a correlation between the presence of HPV and the type of post-therapeutic evolution Figures Figure 1.

The presence of RBP protein 48 positive and can hpv virus cause throat cancer positive cases was associated with local recurrence in 29 cases The presence of TGF protein 41 positive and slowly positive cases was associated with local recurrence in 18 cases The presence of HPV capsid protein 14 positive cases was associated with local recurrence in nine cases Figure 6.

Hpv virus causing throat cancer

Tumoral markers in evolution of tonsillar SCC result of our retrospective study From our data, we can certify as prognostic factors in tonsillar SCC: T stage, N stage, performing or not an elective type of clinical negative neck N0, type of neck dissection, the total dose of radiotherapy. According to some recent studies, the HPV infection may also increase the risk of cardiovascular diseases. Strains of HPV 16 and 18 are strains with a high cancer risk, known to cause almost all cases of cervical cancer while also increasing the risk to develop oropharyngeal cancer[3].

We cannot make statistical significant conclusions referring to the HPV presence in tumoral tissue in tonsillar SCC and long-term prognosis. Cancerul maxilo- facial the presence of HPV in tonsillar tumoral tissue imposes hybridisation in situ or polymerase chain reaction PCR.

Discussion Slaughter et al. They explained the greater risk for multiple primary cancers 8.

Why are HPV-related oral cancers on the rise?

Tobacco and alcohol abuse increase can hpv virus cause throat cancer risk for a second cancer development in patients with oropharyngeal SCC. Tobacco and alcohol abuse are associated with mutations of the p53 protein in patients with OFSCC, being important factors in the molecular progression through carcinogenesis 9. Many clinical studies searched for the p53 protein mutations on surgical specimens from patients with OFSCC. The patients with surgical positive edges for p53 protein mutations have a higher risk of local relapse P53 protein mutations are involved in the loco-regional failure at OFSCC tonsillar with curative radiotherapy The HPV 16 DNA was identified only in primary tumour can hpv virus cause throat cancer and in their metastases in similar manner with cervical cancer 3.

The presence of HPV 16 genome was revealed by polymerase chain reaction PCR or the method of hybridisation in situ, which certified the presence of viral genome included in host cell genome It is necessary to make a study on HPV tonsillar infection in non-smokers and human papilloma virus causing throat cancer consumers.

Hpv virus causes throat cancer. Înțelesul "papillomavirus" în dicționarul Engleză

Our method for HPV identification was immunohistochemistry for p16 protein, which is a specific capsid protein of HPV 16 type, so we cannot certify the presence of HPV genome in all specimens studied.

We were in the situation of the unavailability of the in situ hybridization kits or polymerase chain reaction for HPV 16 type during the study. We have to mention the can hpv virus cause throat cancer cost for identifying viral markers. Sinonimele și antonimele papillomavirus în dicționarul de sinonime Engleză Clinical stadialization represents the primary guide to choose the therapeutic modality, but it is a limited guide.

We expected the genetic analysis to be the method of future, meaning the identification of markers for prevention, therapy and good prognosis. Recent studies showed an inverse correlation between the presence of HPV and p53 protein mutations.

The HPV-positive tumors have genetic alterations associated with a better answer to chemotherapy and with an improved radio-sensitivity. The immune response of the patient is better, because of the immune stimulation realised by viral antigens.