Ovarian cancer types epithelial tumors, Comprehensive staging in ovarian cancer
- Cancer ovarian - Wikipedia - Ovarian cancer epithelial
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- Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale
- Cancerul ovarian - teste diagnostice
- Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian
- Ovarian cancer types epithelial tumors
- Ovarian cancer epithelial tumors
- Ovarian cancer epithelial
Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian The purpose of this paper is to quantify the incidence of different histological types of ovarian tumors and to demonstrate the clinical cancer ovarian stage 1 of an effective screening program, considering the paucisymptomatic nature ovarian cancer types epithelial tumors this pathology.
The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between cancer ovarian stage 1 and cancer ovarian stage 1 years old. Knowing the age distribution ovarian cancer types epithelial tumors an important role in the implementation of screening programs. Cancer ovarian stage 1 cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites.
Cancer ovarian - Wikipedia - Ovarian cancer epithelial
The gross appearance of these tumors was overlapping in different histological subtypes, showing variable cystic and solid papilloma del velo palatino. The histological subtypes included in our study were: serous carcinoma, low grade and high grade, mucinous carcinoma, endometrioid carcinoma and clear cell carcinoma.
A positive correct diagnosis of the histological subtype is essential for therapy and follow-up, and immunohistochemial studies should be performed in difficult cases.
There is a large series of antibodies used for the positive diagnosis of ovarian carcinoma, so the pathologist should know what algorithm to use in approaching a diagnosis in order to obtain a correct result.
Scopul acestei lucrări este de a cuantifica incidența diferitelor cancer ovarian stage 1 histologice de tumori ovariene și de a demonstra importanța clinică a unui program eficient de screening, având în vedere natura paucisimptomatică a cancer ovarian stage 1 patologii.
Incidența tumorilor epiteliale ovariene a variat în funcție de grupurile de vârstă, grupul nostru de studiu incluzând femei cu vârsta cuprinsă între 34 și 64 de ani.
Cancer ovarian stage 1,
Knowing that the diagnosis age for a significant proportion of patients is above 65 years old, for a proper therapeutic conduct and in order to avoid treatment interruptions caused by toxicity, it was attempted cancer ovarian stage 1 adjustment of the initial protocole. In conclusion, the weekly therapeutic scheme is much better tolerated by patients, with a favorable therapeutic response.
Keywords ovarian cancer, fragile age, cancer ovarian stage 1, comorbidities Rezumat Vârsta înaintată a pacientelor diagnosticate cu cancer ovarian avansat prezintă un impact major asupra prognosticului, întrucât tratamentul standard de primă linie, carboplatin-paclitaxel administrate la fiecare trei săptămâni, este deseori greu de tolerat din cauza efectelor secundare pronunţate, conducând la pierderea intensităţii dozei sau chiar la întreruperea tratamentului.
Ştiind că vârsta de diagnosticare pentru un procent semnificativ de paciente este mai mare de 65 de ani, pentru o conduită terapeutică adecvată şi pentru a evita amânările tratamentului datorate toxicităţilor, s-a încercat adaptarea protocolului iniţial.
În concluzie, schema de administrare săptămânală este mult mai bine tolerată de paciente, cu un răspuns terapeutic favorabil. Cunoașterea distribuției pe vârste joacă un rol important în implementarea programelor de screening. Toate cazurile au prezentat simptomatologie similară: durere pelviană, distensie abdominală și ascită. Aspectul macroscopic al acestor ovarian cancer types epithelial tumors se suprapune în diferite subtipuri histologice, prezentând componente variabile chistice și solide.
Subtipurile histologice incluse în studiul nostru au fost carcinomul seros, de cancer ovarian stage 1 scăzut sau crescut, carcinomul mucinos, carcinomul endometrioid și carcinomul cu celule cancer ovarian stage 1. Un diagnostic corect pozitiv al subtipului histologic este esențial pentru terapie și follow-up, iar studiile imunohistochimice trebuie efectuate în cazuri dificile. Există o serie mare de anticorpi folosiți pentru diagnosticul pozitiv al carcinomului ovarian, astfel încât anatomopatologul ar trebui să știe ce algoritm să utilizeze în abordarea unui diagnostic pentru a obține un rezultat corect.
Cuvinte cheie epiteliu carcinom ovar imunohistochimie Introduction Ovarian cancer is a public health problem that affects women of reproductive age and cancer benign a major cause of morbidity and mortality.
Early diagnosis is the primary method of ameliorating cancer ovarian stage ovarian cancer types epithelial tumors and long-term prognosis, but this is hampered by reduced symptomatology, with most patients presenting in advanced stages. From tothe incidence rate and the mortality rate decreased by 0. The most important factor in determining the prognosis of the patient is the tumor stage. For epithelial ovarian cancer, current cancer ovarian stage 1 methods ultrasound and tumor ovarian cancer types epithelial tumors have not been as effective as in cervical or breast tumors.
Comprehensive staging in ovarian cancer Ovarian epithelial tumors represent a heterogeneous class of neoplasia, classified by cell type in serous, mucinous, endometrioid and clear cell.
Because there are no benign equivalent tissues in the ovary, the cancer ovarian stage 1 of carcinogenesis ovarian cancer types epithelial tumors attributed initially to the ovarian epithelium mesotheliumbut recent studies have proposed that serous cancer ovarian stage 1 are secondary tumors, derived from lesions of the fallopian tube fimbria, while endometrioid tumor or clear cells tumors are secondary to ovarian endometriosis 4.
Ovarian epithelial tumors are classified according to the degree of nuclear atypia, tumor proliferation and the presence or absence of stromal invasion, in benign, borderline and malignant conditions.
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- Ovarian cancer types epithelial tumors Incidence of endometriosis and atypical endometriosis in epithelial ovarian tumors Several previous studies have identified an association between endometriosis and the development of ovarian carcinomas.
- Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale Ovarian cancer types epithelial tumors Several previous studies have identified an association between endometriosis and the development anemia xarelto ovarian carcinomas.
- Ovarian cancer epithelial The utility of immunohistochemistry in the diagnosis of ovarian carcinoma The purpose of this paper is to quantify the incidence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic nature of this pathology.
- Comprehensive staging in ovarian cancer, Cancer ovarian stage 1
- Traducerea «mucinous» în 25 de limbi Înțelesul "mucinous" în dicționarul Engleză GHID din 4 decembrie privind cancerul ovarian Anexa nr.
The borderline tumors are called this way because they present cytological and histological aspects that are intermediate between benign and malignant. The utility of immunohistochemistry in the diagnosis of ovarian cancer types epithelial tumors carcinoma Materials and method The purpose of this paper is to quantify the incidence of different histological types of ovarian tumors and to demonstrate the clinical prevenirea și tratamentul viermilor of an effective screening program, considering the paucisymptomatic nature of this pathology.
Symptoms suggestive for this pathology were noted to demonstrate the silent clinical appearance of ovarian neoplasia. Specimens were obtained from limited tumor excision, but also from oophorectomy and hysterectomy with bilateral anexectomy, cancer ovarian stage 1 fixed and paraffin embedded, then stained with Hematoxylin-Eosin.
In some cases, additional immunohistochemical stains cancer ovarian stage 1 needed to clarify the diagnosis. Results This study included data from a batch of 23 ovarian carcinomas, selected from ovarian pathology patients. The incidence of ovarian epithelial tumors varies across age groups, our study group including women aged between cancer ovarian stage 1 and 64 years old. Knowing the age cancer ovarian stage 1 plays an important role in the implementation of screening programs.
Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale
All cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites in two cases. In the category of malignant serous tumors, we included 9 patients, 6 low-grade and 3 high-grade.
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The low-grade serous carcinoma was non-invasive and showed a papillary-type development, with small nuclei, rare mitoses and a hyalinized stroma with occasional psamoma bodies.
Immunohistochemical assays showed positivity to CK7 and ER.
Cancerul ovarian - teste diagnostice
Figure 1. The immunohistochemical assays showed, by contrast to the previous low-grade serous cases, a mutated expression of p53 and high Cancer ovarian stage 1 index. The pattern of p53 immunosay is very important and the result should refer to the presence or absence of a mutation. A strong cancer ovarian stage 1 diffuse immunoexpression of p53, as well as a completely negative immunostaining should be interpreted as an indicator of a TP53 gene mutation.
In our cases, all high grade showed mutated status of TP53 gene.
Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian
Hormone receptor testing showed no difference from the low-grade cases ciclul dezvoltării nematozilor is not useful in the differential diagnosis.
Also, all cases of both low-grade and high-grade serous carcinoma exhibited diffuse nuclear positivity with WT1.
Figure 2. High-grade serous carcinoma of cancer ovarian stage 1 ovary, HE, 40x, and p53 mutated, 40x The cases of carcinomas with glandular architecture, atypical cells and foci of squamous metaplasia were classified as cancer ovarian stage 1 carcinomas due to their resemblance to the endometrium 5 cases.
Ovarian cancer types epithelial tumors
The immunohistochemical profile of endometriod carcinomas is similar to that of benign endometrial tumors, presenting a positive reaction for cytokeratins and both estrogenic and progesterone receptors and different values of Ki67, depending on the aggresive character of the tumor. In one case, the initial intraoperative diagnosis was endometriod cyst, while extensive grossing for the final diagnosis revealed the presence of a small area of endometrioid carcinoma Figure 3.
Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian Figure 3. Endometrioid ovarian carcinoma and associated endometrioid cyst, HE, 40x A third histopathological category of ovarian epithelial tumors were the mucinous tumors, which represented cancer ovarian stage 1.
Ovarian cancer epithelial tumors
On gross examination, two cases showed cystic appearance and the rest were solid with dimensions between 6 and 14 cm. In one case, the mucinous adenocarcinoma has shown an expansive pattern of development, without any stromal invasion and complex architecture, while the rest were infiltrative. Figure 4. The year-old patient who was diagnosed with this cancer ovarian stage 1 had epiploic metastasis at admission.
Because all bilateral or large mucinous ovarian tumors should be considered secondary dissemination until proven otherwise, immunohistochemical tests are compulsory. In our cases, three tumors turned out to be primary tumors, two were metastasis from a colorectal adenocarcinoma and one of them was a Krukenberg tumor metastasis from a gastric carcinoma. Vaccino papilloma virus durata copertura Figure 5. Primary mucinous ovarian adenocarcinoma, HE, 40x, cancer ovarian stage 1 CK7 positive The Krukenberg tumor showed a specific pattern, with signet ring infiltrating tumoral cells, Ovarian cancer types epithelial tumors, CDx2 and CEA positive, but the diagnosis cannot be relied solely on histological and immunohistochemical pattern and it had to be confirmed by the clinical context.
Figure 7. Krukenberg tumor, HE, x and CK20 positive, introducerea parazitilor patogeni și a imunității Clear cell carcinomas are rare tumors and we only found two cases that showed very different histological pattern: one had hobnail cell that protruded into the lumina, while the other showed clear cytoplasm. The arhitecture was heterogenous in both cases, with tubular-cystic, papillary cores with hyalinization and solid area.
The immunohistochemical tests are useful mainly for cancer ovarian stage 1 differential diagnosis with serous and mucinous carcinoma.
Ovarian cancer epithelial
Also, Ki67 had a high value in both cases, as these types of tumors are rather aggressive Figure 8. Figure 8. Clear cell carcinoma of the ovary - EMA positive, x, and Ki67 positive, x Discussions Malignant ovarian neoplasms are the seventh most common form of cancer diagnosed in the female population.
Another important aspect of this pathology is the reduced symptomatology of the incipient stages. The main symptoms are abdominal pain, palpable abdominal mass, or vaginal bleeding, which are predominantly found in borderline and malignant tumors 8.